Tom was our mentor, advisor, and friend—a pioneer in the field of cardio-oncology, making many lasting contributions. He brought basic research to the nascent field of cardio-oncology and inspired many. He served as a mentor, inspiring and motivating many in his extraordinarily affable and humble way.Thomas Lee Force was born on March 25, 1951, in Vandalia, Illinois. He graduated Phi Beta Kappa from Harvard College in 1973, majoring in psychology, although Tom would often admit that his passion in college was music. After taking a year off, he matriculated at Harvard Medical School. He stayed in New England for much of his subsequent training.In 1984, he joined the faculty at Massachusetts General Hospital and Harvard Medical School as an instructor. Initially drawn to clinical imaging research he made seminal observations in the field of echocardiography, resulting in the publication of important manuscripts.At Massachusetts General Hospital, he embarked in a new direction in cardiac signaling, focusing specifically on stress-activated pathways, particularly kinases. At the same time, he quickly rose through the ranks, becoming an Associate Professor at Harvard Medical School.His pioneering work provided unique insights directly relevant to the cardiotoxic effects of targeted therapies. Tom’s research demonstrated a critical role for kinase signaling in the cardiovascular system.In 2006, Tom’s laboratory published a seminal manuscript in Nature Medicine, which opened the door for using cardio-oncology as a novel platform for basic cardiac investigation.
In 2005, Tom moved his laboratory to Thomas Jefferson Medical College in Philadelphia, then to
Temple University in 2012, and finally to Vanderbilt in 2014. He used each of these forums to
advance the burgeoning field of cardio-oncology and to create opportunities for many in the field, particularly young investigators.Tom was the ultimate mentor—he was kind and approachable, and he had incredible humility; he was smart and incisive. It is perhaps no surprise that by the time he retired in 2016, multiple international organizations named leading talks at each annual meeting in his honor, including the International Cardio-Oncology Society Thomas Force Pioneer Award.
** excerpted from JACC: Cardio-Oncology https://doi.org/10.1016/j.jaccao.2020.12.002
Thomas Lee FORCE
“ Tom is a brilliant scientist. He is kind, generous, and always has a way of making you laugh. He motivated my intellectual enthusiasm for and drove me towards cardio-oncology – I heard his lecture at HFSA many years ago when he was talking about the mechanisms of sunitinib cardiotoxicity. I am where I am today in part because he helped bring me into the field. ”
Bonnie Ky, MD, MSCE
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, Editor-In-Chief, JACC Cardio-Oncology
“ Tom is an extremely intelligent scientist and his seminal work years ago really fueled the engine of Cardio-Oncology especially from a basic science perspective.
One of my first memories of Tom was when I asked him to give a lecture in the inaugural Cardio-Oncology international meeting in Houston in 2007 on the coexistence of risk factors that drive CV disease and cancer, he delivered an amazing treatise on the overlap of basic mechanisms that was really quite beautiful. As a leader in the HFSA, he definitely gave me a start in the Cardio-Oncology space through the Society. ”
Daniel Lenihan, MD Washington University in St. Louis School of Medicine President, International Cardio-Oncology Society
Past Recipients of the Thomas L. Force Pioneer Award
2018 Daniela Cardinale, MD, PhD
Daniela Cardinale is director of the cardio-oncology unit at the European Institute of Oncology in Milan, Italy, where she has been working since 1994.Dr Cardinale graduated from the University of Milan in 1987 and specialized in cardiology (Milan 1992). Dr Cardinale worked at the operative unit of intensive cardiac care of the Centro Cardiologico Monzino from 1987 to 1990, and the cardiology division of S Raffaele Hospital of Milan from 1990 to 1994. In 2009, she obtained her PhD in cardiovascular physiopathology from the University of Milan.Her professional experience and investigational interests focus on prevention, early detection, monitoring and treatment of cardiotoxicity; screening of cardiotoxicity in patients with cardiac disease; and malignant pericardial effusion evaluation and intrapericardial treatment. Dr Cardinale has been a key leader in the International Cardio-Oncology Society (IC-OS) since its inception in 2009, and is a fellow of the European Society of Cardiology (ESC).
2019 Joseph R. Carver, MD, FACC
Joseph R. Carver, MD, FACC is a Board Certified cardiologist. He is the Founding Editor of the American Journal of Managed Care and was a Senior Corporate Medical Director at Aetna U.S. Healthcare from 1992-2001 where he was responsible for new program development and directed the National Medical Excellence Program.
From 1999-2001, he was Co-chairperson of the New Jersey and Michigan Working Groups that established voluntary agreements among the insurers in those states to cover the routine costs of clinical trial participation for cancer patients. He is one of the Founding Editors of Cardio-oncology Journal.
He currently is the Bernard Fishman Clinical Professor of Medicine at the Abramson Cancer Center of the University of Pennsylvania, the Chief Operating Officer of the Abramson Family Cancer Research Institute of the Abramson Cancer Center of the University of Pennsylvania and the Chief of Staff of the Abramson Cancer Center. He is the Director of the Thalheimer Cardio-oncology Center at the Abramson Cancer Center and his clinical practice is in the subspecialty of Cardio-oncology. He was the recipient of the IS Ravdin Master Clinician Award at Penn in 2012 and is one of the founding members of Penn Medicine’s Academy of Master Clinicians. He received the ICOS Thomas Force Award in 2019.